Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 0.701 0.083 0.167
biological_process el 70 0.078 0.971 0.655 0.284
biological_process ka 70 0.0 0.682 0.079 0.167
biological_process rf 70 0.0 0.701 0.083 0.167
cellular_component ct 5 0.0 0.169 0.037 0.066
cellular_component el 5 0.009 0.283 0.14 0.106
cellular_component ka 5 0.001 0.188 0.043 0.073
cellular_component rf 5 0.0 0.169 0.037 0.066
disease ct 24 0.001 0.847 0.124 0.229
disease el 24 0.04 0.858 0.6 0.214
disease ka 24 0.0 0.943 0.135 0.255
disease rf 24 0.001 0.847 0.124 0.23
genetic_interaction ct 63 0.0 1.0 0.423 0.327
genetic_interaction el 63 0.0 1.0 0.451 0.333
genetic_interaction ka 63 0.0 1.0 0.937 0.244
genetic_interaction rf 63 0.0 1.0 0.444 0.337
molecular_function ct 49 0.0 0.936 0.16 0.279
molecular_function el 49 0.006 0.907 0.486 0.278
molecular_function ka 49 0.0 0.925 0.161 0.28
molecular_function rf 49 0.0 0.936 0.16 0.279
pathway ct 30 0.001 0.996 0.073 0.181
pathway el 30 0.001 0.207 0.03 0.053
pathway ka 30 0.001 1.0 0.308 0.454
pathway rf 30 0.001 0.176 0.033 0.049
phenotype ct 24 0.0 0.912 0.192 0.275
phenotype el 24 0.026 0.971 0.574 0.271
phenotype ka 24 0.0 1.0 0.23 0.317
phenotype rf 24 0.0 0.907 0.192 0.274
protein_interaction ct 73 0.0 0.741 0.038 0.125
protein_interaction el 73 0.0 0.779 0.039 0.132
protein_interaction ka 73 0.001 1.0 0.347 0.471
protein_interaction rf 73 0.0 0.74 0.037 0.124

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.704 0.131 0.202
integration_mean_by_presence el 73 0.0 0.85 0.079 0.165
integration_mean_by_presence ka 73 0.0 0.842 0.073 0.165
integration_mean_by_presence rf 73 0.0 0.353 0.033 0.072
mean ct 73 0.0 0.704 0.152 0.235
mean el 73 0.0 0.795 0.072 0.141
mean ka 73 0.0 0.846 0.074 0.163
mean rf 73 0.0 0.366 0.044 0.088

CDF plots of non integrated kernels

CDF plots of integrated kernels